Effect of Oral Administration of Magnesium on Cisplatin-Induced Nephrotoxicity in Normal and Streptozocin-Induced Diabetic Rats
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چکیده
منابع مشابه
Effect of Oral Administration of Magnesium on Cisplatin-Induced Nephrotoxicity in Normal and Streptozocin-Induced Diabetic Rats
BACKGROUND Cisplatin (CP) therapy as the most common potent chemotherapeutic process is accompanied by nephrotoxicity. The diabetic state may protect rat kidney against this toxicity, and magnesium (Mg) on the other hand may reduce the glucose level in diabetic animals. OBJECTIVES Current study was planned to investigate the effect of oral administration of magnesium supplementation on CP-ind...
متن کاملeffect of oral administration of magnesium on cisplatin-induced nephrotoxicity in normal and streptozocin-induced diabetic rats
conclusions oral mg supplementation did not protect the cp induced nephrotoxicity in diabetic rats. results cp administration in normoglycemic rats significantly elevated the serum levels of blood urea nitrogen (bun) and creatinine (cr) (p < 0.05). however, coadministration of cp and mg statistically increased the serum levels of bun and cr in both normoglycemic and diabetic animals when compar...
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Background: Cisplatin is an antineoplastic agent used to treat many malignancies; however, the main side effect of cisplatin is nephrotoxicity. The aim of this study was to evaluate the effect of hydration therapy with and without magnesium on prevention of cisplatin-induced nephrotoxicity. Methods: This retrospective study was performed on 46 patients with malignancy who were candidate to rec...
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ژورنال
عنوان ژورنال: Nephro-Urology Monthly
سال: 2013
ISSN: 2251-7006,2251-7014
DOI: 10.5812/numonthly.11624